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Neurologist-recommended Petadolex Pro-Active contains pure butterbur extract to support healthy blood vessel tone in the head, as well as normal blood flow in the brain.† The exclusive, patented processing (U.S. Patent #6,551,626) used to create Petadolex Pro-Active removes toxins naturally present in butterbur, making it the ONLY safe form available. For soothing comfort that improves with continued use, trust Petadolex Pro-Active for your entire family-it's clinically studied to be well tolerated, produces no significant adverse effects and is effective in both adults and children!†
Recommendations: One softgel three times daily for the first four weeks. Thereafter, one softgel twice daily.
Serving Size: 1 Softgel
Amount/Serving
Purple Butterbur(Petasites hybridus)
Petadolex Root Extract standardized to contain 7.5 mg petasins and to be free of harmful levels of pyrrolizidine alkaloids (PAs)
*Daily Value (DV) not established
Other Ingredients: medium chain triglycerides, gelatin, vegetable glycerin, water, and riboflavin color.
Contains No: Sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial flavoring and preservatives. All colors used are from natural sources.
Frequently Asked Questions
I am taking 3 Petadolex® Pro-Active softgels per day with good results. Why do I have to reduce the dosage to 2 per day after the first month?
The recommendations are based on clinical study results. The reduced dosage has been shown to effectively maintain benefits when used on an on-going basis. If you find a higher dosage works better for you, up to three Petadolex® Pro-Active softgels can safely be taken every day.
What’s the difference between Petadolex® Pro-Active and Petadolex Fast-Acting?
Both supplements utilize identical softgel capsules, providing the same patented butterbur extract. The difference is the recommendation dosage. Petadolex® Pro-Active recommends fewer capsules and is meant to be taken every day on an on-going basis, while Petadolex Fast-Acting suggests a higher dose for times when immediate benefit is required.
How Does It Work?:
Key Compounds
Petasites hybridus contains several compounds with bioactive properties.1 Two of these compounds, petasin and isopetasin, have been studied for their ability to support healthy brain blood vessel tone and circulation.†
Blood vessel tone is influenced, in part, through neuralgic, vascular, and chemical factors. This includes biosynthesis of neurochemicals, changes in calcium channel regulation, and activation of pro-inflammatory mediators, resulting in both localized and systemic changes.†2,3
Laboratory research has determined the actions of the key .P. hybridus compounds. Both petasin and isopetasin support healthy vessel relaxation.†4,5 Petasin additionally provides nutritional support for the cellular activity associated with healthy blood vessel wall functioning.†6-9
Clinical Studies
The standardized butterbur extract in Petadolex® was studied in a randomized, double-blind, placebo-controlled study (with inclusion and exclusion criteria designed in compliance with standards established by the International Headache Society). A total of 60 people received either Petadolex® or placebo for 12 weeks. Participants were asked to keep health diaries, which were reviewed at 4 week intervals. Both objective health data and subjective feelings of wellbeing were recorded. Thirty- three individuals were randomized to the Petadolex® group and 27 to the placebo group.10
Compared to placebo, Petadolex® provided significant support of healthy blood vessel tone.† Documentation of subjective feelings revealed that 77% of the participants in the Petadolex® Patented Brain Support† group felt that the product provided beneficial health support, compared to 27% of the individuals taking the placebo.†10
In another placebo-controlled, double-blind, randomized trial, the efficacy of Petadolex® Patented Brain Support† in the support of healthy cranial blood vessel tone was examined with a larger number of individuals. A total of 202 participants completed the study.†11
Participants were blindly randomized into one of three groups: a Petadolex® 150 mg per day group, Petadolex® 100 mg per day group, or the placebo group. The study lasted five months; participants were assessed every four weeks.11
At the conclusion of the study, both the 100 mg extract group and the 150 mg group were noted to have significant blood vessel support compared to the placebo group. However, the group receiving 150 mg reported more support than the 100 mg group.†11
The authors of the study concluded that 150 mg of Petadolex® per day may be an effective nutritional supplement for support of healthy brain blood vessel tone.†11
Petadolex® ASAP clinical study
In an open study on the benefits of immediate dosage Petadolex®, a total of 16 people took 250 mg of Petadolex® ASAP† per day (when support was needed) for 12 weeks.12
Documentation of subjective feelings revealed that 75% of the participants in the Petadolex® ASAP† group felt that the product provided beneficial health support.†12
Pyrrolizidine Alkaloids
Research has suggested that pyrrolizidine alkaloids found in certain plants in the family of Petasites hybridus might be linked to development of cancer.13,14 Petadolex® is free of pyrrolizidine alkaloids.
Recommendations:
Petadolex® Patented Brain Support† : One softgel three times daily for the first four weeks. Thereafter, one softgel twice daily.
Petadolex® ASAP† : Three softgels for immediate benefit, followed two hours later by one additional softgel. For extra support, a fifth softgel may be taken two hours after the fourth. Do not exceed five softgels in a 24-hour period.
Precautions:
Do not use if pregnant or nursing a baby.
How Is It Supplied?:
Petadolex® Patented Brain Support† : 60 softgels per bottle.
Petadolex® ASAP : 10 softgels per carton.
Storage Recommendations:
Store at controlled room temperature, 59° to 86°F (15°-30°C).
References:
1. Monograph. Petasites hybridus. J Altern Med Rev. 2001;6:207-209.
2. Norris J, Ed. Migraine headache. In: Professional Guide to Diseases. 5th ed. Springhouse, Pa: Springhouse Corporation, 1995: 614-616.
3. Hamelsky SW, Stewart WF, Lipton RB. Epidemiology of migraine. Curr Pain Headache Rep. 2001;5:189-194.
4. Thomet OA, Wiesmann UN, Blaser K, Simon HU. Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. Clin Exp Allergy. 2001;31:1310-1320.
5. Thomet OA, Wiesmann UN, Schapowal A, Bizer C, Simon H. Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. Biochem Pharmacol. 2001;61:1041-1047.
6. Bickel D, Roder T, Bestmann HJ, Brune K. Identification and characterization of inhibitors of peptido-leukotriene-synthesis from Petasites hybridus. Planta Med. 1994;60:318-322.
7. Wang GJ, Shum AY, Lin YL, et al. Calcium channel blockade in vascular smooth muscle cells: major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus. J Pharmacol Exp Ther. 2001;297:240-246.
8. Ko WC, Lei CB, Lin YL, Chen CF. Mechanisms of relaxant action of S-petasin and S-isopetasin, sesquiterpenes of Petasites formosanus, in isolated guinea pig trachea. Planta Med. 2001;67:224-229.
9. Ko WC, Lei CB, Lin YL, Chen CF. Relaxant effects of petasins in isolated guinea pig trachea and their structure-activity relationships. Planta Med. 2000;66:650-652.
10. Grossmann M, Schmidramsl H. An extract of petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Therap. 2000;28:430-435.
11. Lipton RB, Gobel H, Wilkes K, Mauskop A. Efficacy of petasites 50 and 75 mg for prophylaxis of migraine: results of a randomized, placebo-controlled study. Neurology 2002;58(S3):A472.
12. Danesch U. Petadolex for the treatment of headache. A profile of a special butterbur extract: pharmacology, safety, and clinical aspects. Townsend Letter for Doctor and Patients. April, 2003. In Press.
13. Yang YC, Yan J, Doerge DR, Chan PC, Fu PP, Chou MW. Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo. Chem Res Toxicol. 2001;14:101-109.
14. Stewart MJ, Steenkamp V. Pyrrolizidine poisoning: a neglected area in human toxicology. Ther Drug Monit. 2001;23:698-708.
Notes:
Caution: Do not use if pregnant or nursing. If taking prescription drugs, consult your healthcare practitioner prior to use.
Petadolex® Pro-Active is distributed by Enzymatic Therapy under license from Weber & Weber. Product of Germany.
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